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5kas

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Current revision (10:44, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5kas' size='340' side='right'caption='[[5kas]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='5kas' size='340' side='right'caption='[[5kas]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kas]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KAS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kas]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KAS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.619&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kar|5kar]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Smpdl3b, Asml3b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kas OCA], [https://pdbe.org/5kas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kas RCSB], [https://www.ebi.ac.uk/pdbsum/5kas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kas ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kas OCA], [http://pdbe.org/5kas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kas RCSB], [http://www.ebi.ac.uk/pdbsum/5kas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kas ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ASM3B_MOUSE ASM3B_MOUSE]] Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358).<ref>PMID:26095358</ref>
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[https://www.uniprot.org/uniprot/ASM3B_MOUSE ASM3B_MOUSE] Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358).<ref>PMID:26095358</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Gorelik, A]]
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[[Category: Gorelik A]]
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[[Category: Heinz, L X]]
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[[Category: Heinz LX]]
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[[Category: Illes, K]]
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[[Category: Illes K]]
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[[Category: Nagar, B]]
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[[Category: Nagar B]]
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[[Category: Superti-Furga, G]]
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[[Category: Superti-Furga G]]
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[[Category: Extracellular]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Phosphocholine]]
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[[Category: Phosphoesterase]]
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Current revision

Murine acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) with phosphocholine

PDB ID 5kas

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OCA

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