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6czb

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Current revision (14:31, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6czb' size='340' side='right'caption='[[6czb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6czb' size='340' side='right'caption='[[6czb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6czb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CZB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6czb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CZB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wop|4wop]], [[3fgn|3fgn]], [[3fmf|3fmf]], [[6cve|6cve]], [[6cvu|6cvu]], [[6cvv|6cvv]], [[6cvf|6cvf]], [[3fpa|3fpa]], [[3fmi|3fmi]], [[6czc|6czc]], [[6czd|6czd]], [[6cze|6cze]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioD, Rv1570, MTCY336.33c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6czb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6czb OCA], [https://pdbe.org/6czb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6czb RCSB], [https://www.ebi.ac.uk/pdbsum/6czb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6czb ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dethiobiotin_synthase Dethiobiotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.3 6.3.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6czb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6czb OCA], [http://pdbe.org/6czb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6czb RCSB], [http://www.ebi.ac.uk/pdbsum/6czb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6czb ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>
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[https://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dethiobiotin synthase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Bruning, J B]]
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[[Category: Bruning JB]]
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[[Category: Polyak, S W]]
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[[Category: Polyak SW]]
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[[Category: Thompson, A P]]
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[[Category: Thompson AP]]
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[[Category: Wegener, K L]]
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[[Category: Wegener KL]]
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[[Category: Enzyme]]
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[[Category: Nucleotide triphosphate binding]]
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[[Category: Synthetase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with uridine triphosphate (UTP) - promiscuous binding mode with disordered nucleoside

PDB ID 6czb

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