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6mfx

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Current revision (06:30, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6mfx' size='340' side='right'caption='[[6mfx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6mfx' size='340' side='right'caption='[[6mfx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mfx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10027 Atcc 10027]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MFX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mfx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MFX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EF:N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide'>9EF</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lgrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9EF:N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide'>9EF</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfx OCA], [http://pdbe.org/6mfx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mfx RCSB], [http://www.ebi.ac.uk/pdbsum/6mfx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfx OCA], [https://pdbe.org/6mfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mfx RCSB], [https://www.ebi.ac.uk/pdbsum/6mfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA]] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
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[https://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mfx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mfx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Linear gramicidin synthase|Linear gramicidin synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 10027]]
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[[Category: Brevibacillus parabrevis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Eivaskhani, M]]
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[[Category: Eivaskhani M]]
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[[Category: Reimer, J M]]
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[[Category: Reimer JM]]
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[[Category: Schmeing, T M]]
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[[Category: Schmeing TM]]
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[[Category: Enzyme]]
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[[Category: Ligase]]
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[[Category: Linear gramicidin]]
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[[Category: Natural product]]
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[[Category: Nonribosomal peptide synthetase]]
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[[Category: Nrp]]
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[[Category: Tailoring domain]]
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Current revision

Crystal structure of a 4-domain construct of a mutant of LgrA in the substrate donation state

PDB ID 6mfx

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