==CO-CRYSTAL STRUCTURE OF TBP RECOGNIZING THE MINOR GROOVE OF A TATA ELEMENT==

<StructureSection load='1vtl' size='340' side='right'caption='[[1vtl]], [[Resolution|resolution]] 2.25&Aring;' scene=''>

<table><tr><td colspan='2'>[[1vtl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VTL FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtl OCA], [http://pdbe.org/1vtl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vtl RCSB], [http://www.ebi.ac.uk/pdbsum/1vtl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vtl ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH]] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The three-dimensional structure of a TATA-box binding polypeptide complexed with the TATA element of the adenovirus major late promoter has been determined by X-ray crystallography at 2.25 A resolution. Binding of the saddle-shaped protein induces a conformational change in the DNA, inducing sharp kinks at either end of the sequence TATAAAAG. Between the kinks, the right-handed double helix is smoothly curved and partially unwound, presenting a widened minor groove to TBP's concave, antiparallel beta-sheet. Side-chain/base interactions are restricted to the minor groove, and include hydrogen bonds, van der Waals contacts and phenylalanine-base stacking interactions.

Co-crystal structure of TBP recognizing the minor groove of a TATA element.,Kim JL, Nikolov DB, Burley SK Nature. 1993 Oct 7;365(6446):520-7. PMID:8413605<ref>PMID:8413605</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1vtl" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Arabidopsis thaliana]]

[[Category: Burley, S K]]

[[Category: Protein-dna complex]]

[[Category: Transcription-dna complex]]