Sandbox Reserved 1092
From Proteopedia
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{{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==5JI1 : Myostatin (GDF8)== | ==5JI1 : Myostatin (GDF8)== | ||
| - | <StructureSection load='5JI1' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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| + | <StructureSection load='5JI1' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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<StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=' | <StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=' | ||
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| + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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== Structure/ Structural highlights == | == Structure/ Structural highlights == | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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| - | </StructureSection> | ||
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It is a grown factor<ref name="patho"/> that is implicated into muscle development in mammals. Myostatin can transmit a message to the nucleus that will promote a gene that lead to the production of ubiquitin. Ubiquitin is a signal of degradation so muscle cells will be destroyed. Indeed, it reduce the mass of the muscle but it also reduces the quantity of [[Myosin]] <ref>Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 [https://doi.org/10.1016/B978-0-323-34126-4.00036-0 DOI:10.1016/B978-0-323-34126-4.00036-0] </ref> which is very important for the cohesion of muscles and for movement. Indeed [[Myosin]] forms filament, and when [[Myosin]] filaments associate with [[Actin]] and consume [[ATP]] it produces muscle movement. | It is a grown factor<ref name="patho"/> that is implicated into muscle development in mammals. Myostatin can transmit a message to the nucleus that will promote a gene that lead to the production of ubiquitin. Ubiquitin is a signal of degradation so muscle cells will be destroyed. Indeed, it reduce the mass of the muscle but it also reduces the quantity of [[Myosin]] <ref>Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 [https://doi.org/10.1016/B978-0-323-34126-4.00036-0 DOI:10.1016/B978-0-323-34126-4.00036-0] </ref> which is very important for the cohesion of muscles and for movement. Indeed [[Myosin]] forms filament, and when [[Myosin]] filaments associate with [[Actin]] and consume [[ATP]] it produces muscle movement. | ||
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'''Related disease''' | '''Related disease''' | ||
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However, myostatin can also be a way to cure some disease: | However, myostatin can also be a way to cure some disease: | ||
| - | If myostatin action is inhibited, researchers have noticed that muscular mass increases.Indeed, | + | If myostatin action is inhibited, researchers have noticed that muscular mass increases <ref name="edumont"/><ref name="patho"/>.Indeed, myostatin and particularly its inhibition can be a solution to cure muscle atrophy disease: let’s focus on the example of OPMD <ref> PMID:31066242</ref>, oculopharyngeal muscular dystrophy: This disease involves that the muscles affected show increased fibrosis and atrophy.This is a late-onset disease, affecting 1 people over 80000. It is characterized by dysphagia and ptosis but also limb weakness when the disease is at a very advanced stage. Researcher have noticed that the inhibition of myostatin, increased the muscle quantity and so it help to reduce the symptoms of OPMD. |
In this case, a monoclonal antibiotic is injected to mice during 10 weeks and the results show that muscle strength and muscle fiber diameter increased and the expression of the markers of muscle fibrosis reduced. However, myostatin does not cure the disease because there was no change in intranuclear inclusion density which is a characteristic of OPMD spread, so, it only treats the symptom. | In this case, a monoclonal antibiotic is injected to mice during 10 weeks and the results show that muscle strength and muscle fiber diameter increased and the expression of the markers of muscle fibrosis reduced. However, myostatin does not cure the disease because there was no change in intranuclear inclusion density which is a characteristic of OPMD spread, so, it only treats the symptom. | ||
| - | In other cases, it is also possible to introduce follistatin to block myostatin because they will form a complex and so it will stop myostatin actions. | + | In other cases, it is also possible to introduce follistatin [[Category:Follistatin]] <ref> PMID:19644449</ref> to block myostatin because they will form a complex and so it will stop myostatin actions. |
Revision as of 17:27, 11 January 2020
| This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115. |
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5JI1 : Myostatin (GDF8)
This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
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