1aar

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[[Image:1aar.jpg|left|200px]]
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{{STRUCTURE_1aar| PDB=1aar | SCENE= }}
{{STRUCTURE_1aar| PDB=1aar | SCENE= }}
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'''STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)'''
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===STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)===
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==Overview==
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Covalent ligation of multiubiquitin chains targets eukaryotic proteins for degradation. In such multiubiquitin chains, successive ubiquitins are linked by an isopeptide bond involving the side chain of Lys48 and the carboxyl group of Gly76. The crystal structure of a diubiquitin conjugate has been determined and refined at 2.3-A resolution. The molecule has internal approximate 2-fold symmetry with multiple hydrophobic and hydrophilic contacts along the 2-fold axis. The structure of the diubiquitin conjugate suggests determinants for recognition of multiubiquitin chains. A model for the interaction of diubiquitin and a ubiquitin conjugating enzyme (E2) is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 1322903 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1322903}}
==About this Structure==
==About this Structure==
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[[Category: Pickart, C M.]]
[[Category: Pickart, C M.]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:03:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:30:08 2008''

Revision as of 13:30, 30 June 2008

Image:1aar.png

Template:STRUCTURE 1aar

STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)

Template:ABSTRACT PUBMED 1322903

About this Structure

1AAR is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2)., Cook WJ, Jeffrey LC, Carson M, Chen Z, Pickart CM, J Biol Chem. 1992 Aug 15;267(23):16467-71. PMID:1322903

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