Sandbox 781

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==Crystal structure of MraY bound to carbacaprazamycin==
==Crystal structure of MraY bound to carbacaprazamycin==
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[http://proteopedia.org/wiki/index.php/4j72 MraY]
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----
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<StructureSection load='6OYH' size='340' side='right' caption='Aricept bound to AChE' scene=''>
<StructureSection load='6OYH' size='340' side='right' caption='Aricept bound to AChE' scene=''>
((You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.))
((You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.))
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DDDDDDD
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== Introduction ==
== Introduction ==
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<scene name='61/612822/Aricept_docks_on_tcache/1'>Aricept docked onto AChE</scene>
<scene name='61/612822/Aricept_docks_on_tcache/1'>Aricept docked onto AChE</scene>

Revision as of 00:38, 17 January 2020

Crystal structure of MraY bound to carbacaprazamycin

MraY



Aricept bound to AChE

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. 3.0 3.1 Hering J, Dunevall E, Ek M, Branden G. Structural basis for selective inhibition of antibacterial target MraY, a membrane-bound enzyme involved in peptidoglycan synthesis. Drug Discov Today. 2018 Jul;23(7):1426-1435. doi: 10.1016/j.drudis.2018.05.020., Epub 2018 May 18. PMID:29778697 doi:http://dx.doi.org/10.1016/j.drudis.2018.05.020
  4. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
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