1abz

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[[Image:1abz.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1abz| PDB=1abz | SCENE= }}
{{STRUCTURE_1abz| PDB=1abz | SCENE= }}
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'''ALPHA-T-ALPHA, A DE NOVO DESIGNED PEPTIDE, NMR, 23 STRUCTURES'''
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===ALPHA-T-ALPHA, A DE NOVO DESIGNED PEPTIDE, NMR, 23 STRUCTURES===
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==Overview==
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alpha t alpha is a 38-residue peptide designed to adopt a helical hairpin conformation in solution (Fezoui Y, Weaver DL Osterhout JJ, 1995, Protein Sci 4:286-295). A previous study of the carboxylate form of alpha t alpha by CD and two-dimensional NMR indicated that the peptide was highly helical and that the helices associated in approximately the intended orientation (Fezoui Y, Weaver DL, Osterhout JJ, 1994, Proc Natl Acad Sci USA 91:3675-3679). Here, the solution structure of alpha t alpha as determined by two-dimensional NMR is reported. A total of 266 experimentally derived distance restraints and 20 dihedral angle restraints derived from J-couplings were used. One-hundred initial structures were generated by distance geometry and refined by dynamical simulated annealing. Twenty-three of the lowest-energy structures consistent with the experimental restraints were analyzed. The results presented here show that alpha t alpha is comprised of two associating helices connected by a turn region.
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(as it appears on PubMed at http://www.pubmed.gov), where 9300486 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9300486}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ABZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ABZ OCA].
==Reference==
==Reference==
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[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:05:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:33:16 2008''

Revision as of 13:33, 30 June 2008

Image:1abz.png

Template:STRUCTURE 1abz

ALPHA-T-ALPHA, A DE NOVO DESIGNED PEPTIDE, NMR, 23 STRUCTURES

Template:ABSTRACT PUBMED 9300486

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of alpha t alpha, a helical hairpin peptide of de novo design., Fezoui Y, Connolly PJ, Osterhout JJ, Protein Sci. 1997 Sep;6(9):1869-77. PMID:9300486

Page seeded by OCA on Mon Jun 30 16:33:16 2008

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