This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6lr6
From Proteopedia
(Difference between revisions)
m (Protected "6lr6" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of human cytoplasmic LRS== |
| - | + | <StructureSection load='6lr6' size='340' side='right'caption='[[6lr6]], [[Resolution|resolution]] 3.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6lr6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LR6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=LSS:5-O-(L-LEUCYLSULFAMOYL)ADENOSINE'>LSS</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lr6 OCA], [http://pdbe.org/6lr6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lr6 RCSB], [http://www.ebi.ac.uk/pdbsum/6lr6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lr6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Acute infantile liver failure-multisystemic involvement syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.<ref>PMID:19426743</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leucine--tRNA ligase]] | ||
| + | [[Category: Cusack, S]] | ||
| + | [[Category: Li, H]] | ||
| + | [[Category: Li, J]] | ||
| + | [[Category: Lin, J Z]] | ||
| + | [[Category: Liu, R J]] | ||
| + | [[Category: Long, T]] | ||
| + | [[Category: Palencia, A]] | ||
| + | [[Category: Wang, E D]] | ||
| + | [[Category: Wang, M Z]] | ||
| + | [[Category: Zhao, J H]] | ||
| + | [[Category: Aminoacylation]] | ||
| + | [[Category: Leur]] | ||
| + | [[Category: Protein translation]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Trna]] | ||
Revision as of 10:09, 27 March 2020
The crystal structure of human cytoplasmic LRS
| |||||||||||
Categories: Large Structures | Leucine--tRNA ligase | Cusack, S | Li, H | Li, J | Lin, J Z | Liu, R J | Long, T | Palencia, A | Wang, E D | Wang, M Z | Zhao, J H | Aminoacylation | Leur | Protein translation | Rna binding protein | Trna
