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6vip
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008== | |
| - | + | <StructureSection load='6vip' size='340' side='right'caption='[[6vip]], [[Resolution|resolution]] 1.36Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vip]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VIP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QXY:{4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone'>QXY</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vip OCA], [http://pdbe.org/6vip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vip RCSB], [http://www.ebi.ac.uk/pdbsum/6vip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vip ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Brown, P J]] | ||
| + | [[Category: Doak, B]] | ||
| + | [[Category: Dong, A]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Gunzburg, M]] | [[Category: Gunzburg, M]] | ||
| - | [[Category: James, L.I]] | ||
| - | [[Category: Arrowsmith, C.H]] | ||
| - | [[Category: Dong, A]] | ||
| - | [[Category: Brown, P.J]] | ||
| - | [[Category: Edwards, A.M]] | ||
[[Category: Headey, S]] | [[Category: Headey, S]] | ||
[[Category: Hong, Z]] | [[Category: Hong, Z]] | ||
| + | [[Category: James, L I]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: The, J]] | [[Category: The, J]] | ||
| - | [[Category: | + | [[Category: Mfp-6008]] |
| - | [[Category: | + | [[Category: Protein binding]] |
| - | [[Category: | + | [[Category: Sgc]] |
| + | [[Category: Transcription]] | ||
| + | [[Category: Tudor]] | ||
Revision as of 04:31, 13 February 2020
TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
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Categories: Large Structures | Arrowsmith, C H | Bountra, C | Brown, P J | Doak, B | Dong, A | Edwards, A M | Gunzburg, M | Headey, S | Hong, Z | James, L I | Structural genomic | The, J | Mfp-6008 | Protein binding | Sgc | Transcription | Tudor
