6mra

From Proteopedia

(Difference between revisions)

Current revision

Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies

Structural highlights

6mra is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an understanding of the antigen reactivity and function of type I NKT cells, our knowledge of type II NKT cells in health and disease remains unclear. Here we describe a population of type II NKT cells that recognise and respond to the microbial antigen, alpha-glucuronosyl-diacylglycerol (alpha-GlcADAG) presented by CD1d, but not the prototypical type I NKT cell agonist, alpha-galactosylceramide. Surprisingly, the crystal structure of a type II NKT TCR-CD1d-alpha-GlcADAG complex reveals a CD1d F'-pocket-docking mode that contrasts sharply with the previously determined A'-roof positioning of a sulfatide-reactive type II NKT TCR. Our data also suggest that diverse type II NKT TCRs directed against distinct microbial or mammalian lipid antigens adopt multiple recognition strategies on CD1d, thereby maximising the potential for type II NKT cells to detect different lipid antigens.

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.,Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J Nat Commun. 2019 Nov 20;10(1):5242. doi: 10.1038/s41467-019-12941-9. PMID:31748533^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J. Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nat Commun. 2019 Nov 20;10(1):5242. doi: 10.1038/s41467-019-12941-9. PMID:31748533 doi:http://dx.doi.org/10.1038/s41467-019-12941-9

1 Structural highlights
2 Publication Abstract from PubMed
3 See Also
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6mra"

@@ Line 3: / Line 3: @@
 <StructureSection load='6mra' size='340' side='right'caption='[[6mra]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mra]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MRA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MRA FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mra OCA], [http://pdbe.org/6mra PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mra RCSB], [http://www.ebi.ac.uk/pdbsum/6mra PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mra ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mra OCA], [https://pdbe.org/6mra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mra RCSB], [https://www.ebi.ac.uk/pdbsum/6mra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mra ProSAT]</span></td></tr>
 </table>
 <div style="background-color:#fffaf0;">
@@ Line 15: / Line 16: @@
 </div>
 <div class="pdbe-citations 6mra" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
 == References ==
 <references/>
@@ Line 20: / Line 24: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Nours, J Le]]
+[[Category: Le Nours J]]
-[[Category: Praveena, T]]
+[[Category: Praveena T]]
-[[Category: Rossjohn, J]]
+[[Category: Rossjohn J]]
-[[Category: Sundararaj, S]]
+[[Category: Sundararaj S]]
-[[Category: Cd1d molecule]]
-[[Category: Immune system]]
-[[Category: Microbial lipid antigen]]
-[[Category: Nkt cell]]

6mra

From Proteopedia

Current revision

Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies

Structural highlights

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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