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1wqk

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<StructureSection load='1wqk' size='340' side='right'caption='[[1wqk]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
<StructureSection load='1wqk' size='340' side='right'caption='[[1wqk]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anthopleura_elegantissima Anthopleura elegantissima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WQK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anthopleura_elegantissima Anthopleura elegantissima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WQK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wqk OCA], [http://pdbe.org/1wqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wqk RCSB], [http://www.ebi.ac.uk/pdbsum/1wqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wqk ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wqk OCA], [https://pdbe.org/1wqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wqk RCSB], [https://www.ebi.ac.uk/pdbsum/1wqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wqk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APT1_ANTEL APT1_ANTEL]] Potently and selectively blocks the HERG potassium voltage-gated channels KCNH2 (HERG1) KCNH6 (HERG2) and KCNH7 (HERG3). Acts by modifying the voltage dependence of the channel gating. Does not induce neurotoxic symptoms when injected into mice.<ref>PMID:12815161</ref>
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[[https://www.uniprot.org/uniprot/APT1_ANTEL APT1_ANTEL]] Potently and selectively blocks the HERG potassium voltage-gated channels KCNH2 (HERG1) KCNH6 (HERG2) and KCNH7 (HERG3). Acts by modifying the voltage dependence of the channel gating. Does not induce neurotoxic symptoms when injected into mice.<ref>PMID:12815161</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 16:24, 27 October 2021

Solution structure of APETx1, a specific peptide inhibitor of human Ether-a-go-go-related gene potassium channels from the venom of the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin

PDB ID 1wqk

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