1wxl
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='1wxl' size='340' side='right'caption='[[1wxl]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''> | <StructureSection load='1wxl' size='340' side='right'caption='[[1wxl]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wxl]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1wxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxl OCA], [https://pdbe.org/1wxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxl RCSB], [https://www.ebi.ac.uk/pdbsum/1wxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxl ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SSRP1_DROME SSRP1_DROME]] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.<ref>PMID:12815073</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 16:30, 27 October 2021
Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT
| |||||||||||
Categories: Drome | Large Structures | Hirose, S | Kasai, N | Morikawa, K | Ohki, I | Tate, S | Tsunaka, Y | Dna binding protein | Fact | Hmg | Ssrp1
