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1wxn
From Proteopedia
(Difference between revisions)
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<StructureSection load='1wxn' size='340' side='right'caption='[[1wxn]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | <StructureSection load='1wxn' size='340' side='right'caption='[[1wxn]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wxn]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1wxn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anthopleura_elegantissima Anthopleura elegantissima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXN FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxn OCA], [https://pdbe.org/1wxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxn RCSB], [https://www.ebi.ac.uk/pdbsum/1wxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxn ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/APT2_ANTEL APT2_ANTEL]] Potently and selectively blocks the acid-sensing ion channel ASIC3 (ACCN3). The blockade is rapid and reversible. Also inhibits heteromeric ASIC2b-ASIC3 (ACCN1-ACCN3) channel, while it has less affinity for ASIC1b-ASIC3 (ACCN2-ACCN3), ASIC1a-ASIC3 (ACCN2-ASIC3).<ref>PMID:15044953</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 16:30, 27 October 2021
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels
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