This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1adt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1adt.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1adt.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1adt| PDB=1adt | SCENE= }}
{{STRUCTURE_1adt| PDB=1adt | SCENE= }}
-
'''EARLY E2A DNA-BINDING PROTEIN'''
+
===EARLY E2A DNA-BINDING PROTEIN===
-
==Overview==
+
<!--
-
The adenovirus single-stranded DNA binding protein (Ad DBP) is a multifunctional protein required, amongst other things, for DNA replication and transcription control. It binds to single- and double-stranded DNA, as well as to RNA, in a sequence-independent manner. Like other single-stranded DNA binding proteins, it binds ssDNA, cooperatively. We report the crystal structure, at 2.6 A resolution, of the nucleic acid binding domain. This domain is active in DNA replication. The protein contains two zinc atoms in different, novel coordinations. The zinc atoms appear to be required for the stability of the protein fold rather than being involved in direct contacts with the DNA. The crystal structure shows that the protein contains a 17 amino acid C-terminal extension which hooks onto a second molecule, thereby forming a protein chain. Deletion of this C-terminal arm reduces cooperativity in DNA binding, suggesting a hook-on model for cooperativity. Based on this structural work and mutant studies, we propose that DBP forms a protein core around which the single-stranded DNA winds.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8039495}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8039495 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8039495}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Ssdna binding protein]]
[[Category: Ssdna binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:08:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:38:25 2008''

Revision as of 13:38, 30 June 2008

Image:1adt.png

Template:STRUCTURE 1adt

EARLY E2A DNA-BINDING PROTEIN

Template:ABSTRACT PUBMED 8039495

About this Structure

1ADT is a Single protein structure of sequence from Human adenovirus 5. Full crystallographic information is available from OCA.

Reference

Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding., Tucker PA, Tsernoglou D, Tucker AD, Coenjaerts FE, Leenders H, van der Vliet PC, EMBO J. 1994 Jul 1;13(13):2994-3002. PMID:8039495

Page seeded by OCA on Mon Jun 30 16:38:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1adt"
Personal tools