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1wdz

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<StructureSection load='1wdz' size='340' side='right'caption='[[1wdz]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
<StructureSection load='1wdz' size='340' side='right'caption='[[1wdz]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wdz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WDZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wdz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WDZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wdz OCA], [http://pdbe.org/1wdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wdz RCSB], [http://www.ebi.ac.uk/pdbsum/1wdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wdz ProSAT], [http://www.topsan.org/Proteins/RSGI/1wdz TOPSAN]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wdz OCA], [https://pdbe.org/1wdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wdz RCSB], [https://www.ebi.ac.uk/pdbsum/1wdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wdz ProSAT], [https://www.topsan.org/Proteins/RSGI/1wdz TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
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[[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 16:19, 27 October 2021

Crystal structure of RCB domain of IRSp53

PDB ID 1wdz

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