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1ae7

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[[Image:1ae7.gif|left|200px]]
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{{Seed}}
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[[Image:1ae7.png|left|200px]]
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{{STRUCTURE_1ae7| PDB=1ae7 | SCENE= }}
{{STRUCTURE_1ae7| PDB=1ae7 | SCENE= }}
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'''NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2'''
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===NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2===
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==Overview==
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The three-dimensional structure of notexin has been solved by molecular replacement methods. The structure has been refined at 2.0 A resolution to a crystallographic R-value of 16.5% with good stereo-chemistry. The core of the protein is very similar to other phospholipase A2s (PLA2 s) but several parts of the molecule are distinctly different. The most significant differences from PLA2 s from bovine pancreas and rattlesnake occur in the stretches 56-80 and 85-89. Residue 69, which has been shown to be important for phospholipase binding, has a different conformation and different interactions than in other known PLA2s. The C alpha positions for residues 86-88 differ by about 6 A from both the bovine and the rattlesnake enzyme. The crystals contain no Ca2+ ions. Instead, a water molecule occupies the calcium site.
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The line below this paragraph, {{ABSTRACT_PUBMED_1568473}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1568473 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1568473}}
==About this Structure==
==About this Structure==
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[[Category: Presynaptic neurotoxin]]
[[Category: Presynaptic neurotoxin]]
[[Category: Venom]]
[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:09:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:39:42 2008''

Revision as of 13:39, 30 June 2008

Image:1ae7.png

Template:STRUCTURE 1ae7

NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2

Template:ABSTRACT PUBMED 1568473

About this Structure

1AE7 is a Single protein structure of sequence from Notechis scutatus scutatus. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:1568473

Page seeded by OCA on Mon Jun 30 16:39:42 2008

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