User:Ivan E. Wang/Sandbox 1
From Proteopedia
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Retinal pigment epithelium 65 (RPE65) also known as retinoid isomerohydrolase is a 65 kDa enzyme located within the human retinal pigment epithelium cells responsible for the chemical conversion of ''all-trans''-retinyl ester to ''11-cis''-retinol in the visual cycle. | Retinal pigment epithelium 65 (RPE65) also known as retinoid isomerohydrolase is a 65 kDa enzyme located within the human retinal pigment epithelium cells responsible for the chemical conversion of ''all-trans''-retinyl ester to ''11-cis''-retinol in the visual cycle. | ||
| - | ( | + | (PLACEHOLDER This is a default text for your page '''Ivan E. Wang/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. |
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.) | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.) | ||
= Function = | = Function = | ||
| - | == Structural Features | + | == Structural Features of RPE65 == |
| - | == Structure alignment of RPE65 == | ||
== Enzymatic Catalyzed Reaction == | == Enzymatic Catalyzed Reaction == | ||
| + | |||
= Protein-Ligand Interaction = | = Protein-Ligand Interaction = | ||
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== Exogenous Ligands == | == Exogenous Ligands == | ||
| + | === '''Emixustat (ACU-4429)''' === | ||
| + | Emixustat (ACU-4429) is an investigational small molecule inhibitor of RPE65 first invented by a British-American chemist, Ian L. Scott. In 2008, Acucela Inc. partnered with Otsuka Pharmaceutical Company for the development of emixustat as a potential inhibiter of RPE65. Currently emixustat is in Phase III clinical trials in the United States for the potential treatment of Stargard's disease, a juvenile form of atrophic (dry) age dependent macular degeneration (AMD). | ||
| + | Formulated as an hydrochloride salt, emixustat hydrochloride is taken by mouth and is known as a visual cycle modulator (VCM). | ||
= Mutations = | = Mutations = | ||
Revision as of 17:47, 28 January 2020
Retinal Pigment Epithelium 65 (Retinoid Isomerohydrolase)
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
