6ul4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11== | |
| - | + | <StructureSection load='6ul4' size='340' side='right'caption='[[6ul4]], [[Resolution|resolution]] 3.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ul4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UL4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ul4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ul4 OCA], [http://pdbe.org/6ul4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ul4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ul4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ul4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bontoxilysin]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jin, R]] | ||
| + | [[Category: Lam, K]] | ||
| + | [[Category: Antitoxin]] | ||
| + | [[Category: Receptor-binding domain]] | ||
| + | [[Category: Toxin]] | ||
| + | [[Category: Toxin-antitoxin complex]] | ||
| + | [[Category: Vhh]] | ||
Revision as of 06:56, 4 March 2020
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11
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