This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1aeu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1aeu.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1aeu.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1aeu| PDB=1aeu | SCENE= }}
{{STRUCTURE_1aeu| PDB=1aeu | SCENE= }}
-
'''SPECIFICITY OF LIGAND BINDING IN A POLAR CAVITY OF CYTOCHROME C PEROXIDASE (2-METHYLIMIDAZOLE)'''
+
===SPECIFICITY OF LIGAND BINDING IN A POLAR CAVITY OF CYTOCHROME C PEROXIDASE (2-METHYLIMIDAZOLE)===
-
==Overview==
+
<!--
-
Conformational changes that gate the access of substrates or ligands to an active site are important features of enzyme function. In this report, we describe an unusual example of a structural rearrangement near a buried artificial cavity in cytochrome c peroxidase that occurs on binding protonated benzimidazole. A hinged main-chain rotation at two residues (Pro 190 and Asn 195) results in a surface loop rearrangement that opens a large solvent-accessible channel for the entry of ligands to an otherwise inaccessible binding site. The trapping of this alternate conformational state provides a unique view of the extent to which protein dynamics can allow small molecule penetration into buried protein cavities.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8673607}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8673607 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8673607}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Peroxidase]]
[[Category: Peroxidase]]
[[Category: Transit peptide]]
[[Category: Transit peptide]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:10:38 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:42:01 2008''

Revision as of 13:42, 30 June 2008

Image:1aeu.png

Template:STRUCTURE 1aeu

SPECIFICITY OF LIGAND BINDING IN A POLAR CAVITY OF CYTOCHROME C PEROXIDASE (2-METHYLIMIDAZOLE)

Template:ABSTRACT PUBMED 8673607

About this Structure

1AEU is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity., Fitzgerald MM, Musah RA, McRee DE, Goodin DB, Nat Struct Biol. 1996 Jul;3(7):626-31. PMID:8673607

Page seeded by OCA on Mon Jun 30 16:42:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aeu"
Personal tools