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6j7x

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Current revision (10:03, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6j7x' size='340' side='right'caption='[[6j7x]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='6j7x' size='340' side='right'caption='[[6j7x]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6j7x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J7X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6j7x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J7X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTAR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RABGGTB, GGTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YKT6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7x OCA], [https://pdbe.org/6j7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j7x RCSB], [https://www.ebi.ac.uk/pdbsum/6j7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j7x OCA], [http://pdbe.org/6j7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j7x RCSB], [http://www.ebi.ac.uk/pdbsum/6j7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j7x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YKT6_HUMAN YKT6_HUMAN]] Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.<ref>PMID:15215310</ref> <ref>PMID:9211930</ref> [[http://www.uniprot.org/uniprot/PGTB2_HUMAN PGTB2_HUMAN]] Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
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[https://www.uniprot.org/uniprot/PTAR1_HUMAN PTAR1_HUMAN]
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== References ==
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<references/>
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==See Also==
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*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein geranylgeranyltransferase type II]]
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[[Category: Fukai S]]
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[[Category: Fukai, S]]
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[[Category: Goto-Ito S]]
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[[Category: Goto-Ito, S]]
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[[Category: Sato Y]]
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[[Category: Sato, Y]]
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[[Category: Yamagata A]]
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[[Category: Yamagata, A]]
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[[Category: Lipid binding protein]]
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[[Category: Lipid transferase]]
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Current revision

Complex of GGTaseIII, farnesyl-Ykt6, and GGPP

PDB ID 6j7x

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