6tpj

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Current revision (13:06, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6tpj' size='340' side='right'caption='[[6tpj]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
<StructureSection load='6tpj' size='340' side='right'caption='[[6tpj]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tpj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TPJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tpj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TPJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCRTR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpj OCA], [https://pdbe.org/6tpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tpj RCSB], [https://www.ebi.ac.uk/pdbsum/6tpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpj OCA], [http://pdbe.org/6tpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tpj RCSB], [http://www.ebi.ac.uk/pdbsum/6tpj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN]] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
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[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6tpj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6tpj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ali, A]]
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[[Category: Pyrococcus abyssi GE5]]
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[[Category: Bennett, K A]]
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[[Category: Ali A]]
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[[Category: Brown, J D]]
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[[Category: Bennett KA]]
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[[Category: Bucknell, S J]]
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[[Category: Brown JD]]
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[[Category: Christopher, J A]]
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[[Category: Bucknell SJ]]
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[[Category: Congreve, M]]
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[[Category: Christopher JA]]
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[[Category: Cooke, R M]]
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[[Category: Congreve M]]
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[[Category: Cseke, G]]
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[[Category: Cooke RM]]
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[[Category: Dore, A S]]
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[[Category: Cseke G]]
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[[Category: Errey, J C]]
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[[Category: Dore AS]]
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[[Category: Graaf, C de]]
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[[Category: Errey JC]]
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[[Category: Jazayeri, A]]
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[[Category: Jazayeri A]]
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[[Category: Marshall, F H]]
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[[Category: Marshall FH]]
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[[Category: Mason, J S]]
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[[Category: Mason JS]]
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[[Category: Mould, R]]
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[[Category: Mould R]]
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[[Category: Patel, J C]]
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[[Category: Patel JC]]
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[[Category: Rappas, M]]
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[[Category: Rappas M]]
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[[Category: Tehan, B G]]
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[[Category: Tehan BG]]
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[[Category: Weir, M]]
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[[Category: Weir M]]
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[[Category: Gpcr]]
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[[Category: De Graaf C]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution

PDB ID 6tpj

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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