6tq4

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Current revision (13:07, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6tq4' size='340' side='right'caption='[[6tq4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6tq4' size='340' side='right'caption='[[6tq4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TQ4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TQ4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NV8:2-[1-(phenylsulfonyl)-1,8-diazaspiro[4.5]decan-8-yl]-1,3-benzoxazole'>NV8</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.299&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6to7|6to7]], [[6tod|6tod]], [[6tos|6tos]], [[6tot|6tot]], [[6tp6|6tp6]], [[6tp3|6tp3]], [[6tp4|6tp4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NV8:2-[1-(phenylsulfonyl)-1,8-diazaspiro[4.5]decan-8-yl]-1,3-benzoxazole'>NV8</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCRTR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tq4 OCA], [https://pdbe.org/6tq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tq4 RCSB], [https://www.ebi.ac.uk/pdbsum/6tq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tq4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tq4 OCA], [http://pdbe.org/6tq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tq4 RCSB], [http://www.ebi.ac.uk/pdbsum/6tq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tq4 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
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[https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6tq4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6tq4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ali, A]]
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[[Category: Ali A]]
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[[Category: Bennett, K A]]
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[[Category: Bennett KA]]
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[[Category: Brown, J D]]
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[[Category: Brown JD]]
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[[Category: Bucknell, S J]]
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[[Category: Bucknell SJ]]
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[[Category: Christopher, J A]]
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[[Category: Christopher JA]]
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[[Category: Congreve, M]]
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[[Category: Congreve M]]
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[[Category: Cooke, R M]]
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[[Category: Cooke RM]]
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[[Category: Cseke, G]]
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[[Category: Cseke G]]
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[[Category: Dore, A S]]
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[[Category: Dore AS]]
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[[Category: Errey, J C]]
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[[Category: Errey JC]]
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[[Category: Graaf, C de]]
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[[Category: Jazayeri A]]
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[[Category: Jazayeri, A]]
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[[Category: Marshall FH]]
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[[Category: Marshall, F H]]
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[[Category: Mason JS]]
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[[Category: Mason, J S]]
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[[Category: Mould R]]
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[[Category: Mould, R]]
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[[Category: Patel JC]]
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[[Category: Patel, J C]]
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[[Category: Rappas M]]
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[[Category: Rappas, M]]
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[[Category: Tehan BG]]
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[[Category: Tehan, B G]]
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[[Category: Weir M]]
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[[Category: Weir, M]]
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[[Category: De Graaf C]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the Orexin-1 receptor in complex with Compound 16

PDB ID 6tq4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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