This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6tq4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:07, 24 January 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6tq4' size='340' side='right'caption='[[6tq4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6tq4' size='340' side='right'caption='[[6tq4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6tq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TQ4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6tq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TQ4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NV8:2-[1-(phenylsulfonyl)-1,8-diazaspiro[4.5]decan-8-yl]-1,3-benzoxazole'>NV8</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.299&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6to7|6to7]], [[6tod|6tod]], [[6tos|6tos]], [[6tot|6tot]], [[6tp6|6tp6]], [[6tp3|6tp3]], [[6tp4|6tp4]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NV8:2-[1-(phenylsulfonyl)-1,8-diazaspiro[4.5]decan-8-yl]-1,3-benzoxazole'>NV8</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCRTR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tq4 OCA], [https://pdbe.org/6tq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tq4 RCSB], [https://www.ebi.ac.uk/pdbsum/6tq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tq4 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tq4 OCA], [http://pdbe.org/6tq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tq4 RCSB], [http://www.ebi.ac.uk/pdbsum/6tq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tq4 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
+
[https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 6tq4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6tq4" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ali, A]]
+
[[Category: Ali A]]
-
[[Category: Bennett, K A]]
+
[[Category: Bennett KA]]
-
[[Category: Brown, J D]]
+
[[Category: Brown JD]]
-
[[Category: Bucknell, S J]]
+
[[Category: Bucknell SJ]]
-
[[Category: Christopher, J A]]
+
[[Category: Christopher JA]]
-
[[Category: Congreve, M]]
+
[[Category: Congreve M]]
-
[[Category: Cooke, R M]]
+
[[Category: Cooke RM]]
-
[[Category: Cseke, G]]
+
[[Category: Cseke G]]
-
[[Category: Dore, A S]]
+
[[Category: Dore AS]]
-
[[Category: Errey, J C]]
+
[[Category: Errey JC]]
-
[[Category: Graaf, C de]]
+
[[Category: Jazayeri A]]
-
[[Category: Jazayeri, A]]
+
[[Category: Marshall FH]]
-
[[Category: Marshall, F H]]
+
[[Category: Mason JS]]
-
[[Category: Mason, J S]]
+
[[Category: Mould R]]
-
[[Category: Mould, R]]
+
[[Category: Patel JC]]
-
[[Category: Patel, J C]]
+
[[Category: Rappas M]]
-
[[Category: Rappas, M]]
+
[[Category: Tehan BG]]
-
[[Category: Tehan, B G]]
+
[[Category: Weir M]]
-
[[Category: Weir, M]]
+
[[Category: De Graaf C]]
-
[[Category: Gpcr]]
+
-
[[Category: Membrane protein]]
+

Current revision

Crystal structure of the Orexin-1 receptor in complex with Compound 16

PDB ID 6tq4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6tq4"
Personal tools