4ajf

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<StructureSection load='4ajf' size='340' side='right'caption='[[4ajf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4ajf' size='340' side='right'caption='[[4ajf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ajf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F03:N-(4-OXO-3H-QUINAZOLIN-2-YL)ACETAMIDE'>F03</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F03:N-(4-OXO-3H-QUINAZOLIN-2-YL)ACETAMIDE'>F03</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajg|4ajg]], [[4ajm|4ajm]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajg|4ajg]], [[4ajm|4ajm]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajf OCA], [http://pdbe.org/4ajf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ajf RCSB], [http://www.ebi.ac.uk/pdbsum/4ajf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajf OCA], [https://pdbe.org/4ajf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajf RCSB], [https://www.ebi.ac.uk/pdbsum/4ajf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
==See Also==
==See Also==

Revision as of 05:36, 25 August 2022

Identification and structural characterization of PDE10 fragment inhibitors

PDB ID 4ajf

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