1yx8

From Proteopedia

(Difference between revisions)

Revision as of 16:34, 3 November 2021

NMR structure of Calsensin, 20 low energy structures.

Structural highlights

1yx8 is a 1 chain structure with sequence from Green horse leech. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1yx7
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CLSS_HAEMA] May function as a trigger protein which interacts with a larger protein. May mediate calcium-dependent signal transduction events in the growth cones and axons of a small group of sensory neurons which fasciculate in a single axon tract.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Calsensin is an EF-hand calcium-binding protein expressed by a subset of peripheral sensory neurons that fasciculate into a single tract in the leech central nervous system. Calsensin is a 9-kD protein with two EF-hand calcium-binding motifs. Using multidimensional NMR spectroscopy we have determined the solution structure and backbone dynamics of calcium-bound Calsensin. Calsensin consists of four helices forming a unicornate-type four-helix bundle. The residues in the third helix undergo slow conformational exchange indicating that the motion of this helix is associated with calciumbinding. The backbone dynamics of the protein as measured by (15)N relaxation rates and heteronuclear NOEs correlate well with the three-dimensional structure. Furthermore, comparison of the structure of Calsensin with other members of the EF-hand calcium-binding protein family provides insight into plausible mechanisms of calcium and target protein binding.

Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein.,Venkitaramani DV, Fulton DB, Andreotti AH, Johansen KM, Johansen J Protein Sci. 2005 Jul;14(7):1894-901. Epub 2005 Jun 3. PMID:15937283^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Venkitaramani DV, Fulton DB, Andreotti AH, Johansen KM, Johansen J. Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein. Protein Sci. 2005 Jul;14(7):1894-901. Epub 2005 Jun 3. PMID:15937283 doi:10.1110/ps.051412605

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yx8"

@@ Line 3: / Line 3: @@
 <StructureSection load='1yx8' size='340' side='right'caption='[[1yx8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1yx8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Green_horse_leech Green horse leech]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YX8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1yx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Green_horse_leech Green horse leech]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YX8 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yx7|1yx7]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yx7|1yx7]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx8 OCA], [http://pdbe.org/1yx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yx8 RCSB], [http://www.ebi.ac.uk/pdbsum/1yx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yx8 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx8 OCA], [https://pdbe.org/1yx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yx8 RCSB], [https://www.ebi.ac.uk/pdbsum/1yx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yx8 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CLSS_HAEMA CLSS_HAEMA]] May function as a trigger protein which interacts with a larger protein. May mediate calcium-dependent signal transduction events in the growth cones and axons of a small group of sensory neurons which fasciculate in a single axon tract.
+[[https://www.uniprot.org/uniprot/CLSS_HAEMA CLSS_HAEMA]] May function as a trigger protein which interacts with a larger protein. May mediate calcium-dependent signal transduction events in the growth cones and axons of a small group of sensory neurons which fasciculate in a single axon tract.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1yx8

From Proteopedia

Revision as of 16:34, 3 November 2021

NMR structure of Calsensin, 20 low energy structures.

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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