1afx

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{{STRUCTURE_1afx| PDB=1afx | SCENE= }}
{{STRUCTURE_1afx| PDB=1afx | SCENE= }}
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'''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES'''
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===UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES===
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==Overview==
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The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 10074938 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10074938}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].
==Reference==
==Reference==
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[[Category: Ribosomal rna]]
[[Category: Ribosomal rna]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:13:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:45:57 2008''

Revision as of 13:46, 30 June 2008

Image:1afx.png

Template:STRUCTURE 1afx

UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES

Template:ABSTRACT PUBMED 10074938

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938

Page seeded by OCA on Mon Jun 30 16:45:57 2008

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