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1p9j

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<StructureSection load='1p9j' size='340' side='right'caption='[[1p9j]], [[NMR_Ensembles_of_Models | 36 NMR models]]' scene=''>
<StructureSection load='1p9j' size='340' side='right'caption='[[1p9j]], [[NMR_Ensembles_of_Models | 36 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1p9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1p9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9J FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGF-alpha and EGF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGF-alpha and EGF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9j OCA], [http://pdbe.org/1p9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p9j RCSB], [http://www.ebi.ac.uk/pdbsum/1p9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9j OCA], [https://pdbe.org/1p9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9j RCSB], [https://www.ebi.ac.uk/pdbsum/1p9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN]] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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[[https://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN]] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 08:15, 10 November 2021

Solution structure and dynamics of the EGF/TGF-alpha chimera T1E

PDB ID 1p9j

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