1agg

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{{STRUCTURE_1agg| PDB=1agg | SCENE= }}
{{STRUCTURE_1agg| PDB=1agg | SCENE= }}
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'''THE SOLUTION STRUCTURE OF OMEGA-AGA-IVB, A P-TYPE CALCIUM CHANNEL ANTAGONIST FROM THE VENOM OF AGELENOPSIS APERTA'''
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===THE SOLUTION STRUCTURE OF OMEGA-AGA-IVB, A P-TYPE CALCIUM CHANNEL ANTAGONIST FROM THE VENOM OF AGELENOPSIS APERTA===
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==Overview==
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The 48 amino acid peptides omega-Aga-IVA and omega-Aga-IVB are the first agents known to specifically block P-type calcium channels in mammalian brain, thus complementing the existing suite of pharmacological tools used for characterizing calcium channels. These peptides provide a new set of probes for studies aimed at elucidating the structural basis underlying the subtype specificity of calcium channel antagonists. We used 288 NMR-derived constraints in a protocol combining distance geometry and molecular dynamics employing the program DGII, followed by energy minimization with Discover to derive the three-dimensional structure of omega-Aga-IVB. The toxin consists of a well-defined core region, comprising seven solvent-shielded residues and a well-defined triple-stranded beta-sheet. Four loop regions have average backbone rms deviations between 0.38 and 1.31 A, two of which are well-defined type-II beta-turns. Other structural features include disordered C- and N-termini and several conserved basic amino acids that are clustered on one face of the molecule. The reported structure suggests a possible surface for interaction with the channel. This surface contains amino acids that are identical to those of another known P-type calcium channel antagonist, omega-Aga-IVA, and is rich in basic residues that may have a role in binding to the anionic sites in the extracellular regions of the calcium channel.
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(as it appears on PubMed at http://www.pubmed.gov), where 7703698 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7703698}}
==About this Structure==
==About this Structure==
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1AGG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agelenopsis_aperta Agelenopsis aperta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGG OCA].
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1AGG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agelenopsis_aperta Agelenopsis aperta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGG OCA].
==Reference==
==Reference==
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[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
[[Category: P-type calcium channel antagonist]]
[[Category: P-type calcium channel antagonist]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:14:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:47:55 2008''

Revision as of 13:47, 30 June 2008

Image:1agg.png

Template:STRUCTURE 1agg

THE SOLUTION STRUCTURE OF OMEGA-AGA-IVB, A P-TYPE CALCIUM CHANNEL ANTAGONIST FROM THE VENOM OF AGELENOPSIS APERTA

Template:ABSTRACT PUBMED 7703698

About this Structure

1AGG is a Single protein structure of sequence from Agelenopsis aperta. Full experimental information is available from OCA.

Reference

The solution structure of omega-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta., Reily MD, Thanabal V, Adams ME, J Biomol NMR. 1995 Feb;5(2):122-32. PMID:7703698

Page seeded by OCA on Mon Jun 30 16:47:55 2008

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