4c2s

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<StructureSection load='4c2s' size='340' side='right'caption='[[4c2s]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
<StructureSection load='4c2s' size='340' side='right'caption='[[4c2s]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2s OCA], [http://pdbe.org/4c2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c2s RCSB], [http://www.ebi.ac.uk/pdbsum/4c2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2s OCA], [https://pdbe.org/4c2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2s RCSB], [https://www.ebi.ac.uk/pdbsum/4c2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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[[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Henriksen, A]]
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[[Category: Henriksen A]]
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[[Category: Palcic, M]]
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[[Category: Palcic M]]
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[[Category: Weadge, J T]]
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[[Category: Weadge JT]]
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[[Category: Abo]]
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[[Category: Blood group antigen]]
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[[Category: Glycosylation]]
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[[Category: Gta]]
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[[Category: Transferase]]
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Revision as of 17:22, 7 September 2022

Crystal structure of the fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA P156L mutant) in complex with UDP and deoxy-H-antigen acceptor

PDB ID 4c2s

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