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4c45

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<StructureSection load='4c45' size='340' side='right'caption='[[4c45]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='4c45' size='340' side='right'caption='[[4c45]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C45 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C45 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4a-hydroxytetrahydrobiopterin_dehydratase 4a-hydroxytetrahydrobiopterin dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.96 4.2.1.96] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [https://pdbe.org/4c45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [https://www.ebi.ac.uk/pdbsum/4c45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c45 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [http://pdbe.org/4c45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [http://www.ebi.ac.uk/pdbsum/4c45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c45 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PHS2_HUMAN PHS2_HUMAN]] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
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[[https://www.uniprot.org/uniprot/PHS2_HUMAN PHS2_HUMAN]] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Canning, P]]
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[[Category: Canning P]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Kiyani W]]
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[[Category: Kiyani, W]]
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[[Category: Kopec J]]
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[[Category: Kopec, J]]
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[[Category: Shrestha L]]
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[[Category: Shrestha, L]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M]]
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[[Category: Yue WW]]
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[[Category: Yue, W W]]
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[[Category: Von Delft F]]
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[[Category: Lyase]]
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Revision as of 17:25, 7 September 2022

Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)

PDB ID 4c45

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