1zye

From Proteopedia

(Difference between revisions)

Revision as of 09:39, 9 September 2020

Crystal structure analysis of Bovine Mitochondrial Peroxiredoxin III

Structural highlights

1zye is a 12 chain structure with sequence from Bovin. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:	Peroxiredoxin, with EC number 1.11.1.15
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PRDX3_BOVIN] Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

A crystal structure is reported for the C168S mutant of a typical 2-Cys peroxiredoxin III (Prx III) from bovine mitochondria at a resolution of 3.3 A. Prx III is present as a two-ring catenane comprising two interlocking dodecameric toroids that are assembled from basic dimeric units. Each ring has an external diameter of 150 A and encompasses a central cavity that is 70 A in width. The concatenated dodecamers are inclined at an angle of 55 degrees, which provides a large contact surface between the rings. Dimer-dimer contacts involved in toroid formation are hydrophobic in nature, whereas the 12 areas of contact between interlocked rings arise from polar interactions. These two major modes of subunit interaction provide important insights into possible mechanisms of catenane formation.

Bovine mitochondrial peroxiredoxin III forms a two-ring catenane.,Cao Z, Roszak AW, Gourlay LJ, Lindsay JG, Isaacs NW Structure. 2005 Nov;13(11):1661-4. PMID:16271889^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cao Z, Roszak AW, Gourlay LJ, Lindsay JG, Isaacs NW. Bovine mitochondrial peroxiredoxin III forms a two-ring catenane. Structure. 2005 Nov;13(11):1661-4. PMID:16271889 doi:10.1016/j.str.2005.07.021

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zye"

@@ Line 1: / Line 1: @@
-==Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III==
+==Crystal structure analysis of Bovine Mitochondrial Peroxiredoxin III==
 <StructureSection load='1zye' size='340' side='right'caption='[[1zye]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zye]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zye]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZYE FirstGlance]. <br>
 </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zye OCA], [http://pdbe.org/1zye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zye RCSB], [http://www.ebi.ac.uk/pdbsum/1zye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zye ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1zye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zye OCA], [http://pdbe.org/1zye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zye RCSB], [http://www.ebi.ac.uk/pdbsum/1zye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zye ProSAT]</span></td></tr>
 </table>
 == Function ==

1zye

From Proteopedia

Revision as of 09:39, 9 September 2020

Crystal structure analysis of Bovine Mitochondrial Peroxiredoxin III

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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