This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

4c5c

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 17:27, 7 September 2022

The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ADP and D-ala-D-ala

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c5c"

@@ Line 3: / Line 3: @@
 <StructureSection load='4c5c' size='340' side='right'caption='[[4c5c]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4c5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C5C FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4c5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C5C FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c5a|4c5a]], [[4c5b|4c5b]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5c OCA], [https://pdbe.org/4c5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c5c RCSB], [https://www.ebi.ac.uk/pdbsum/4c5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c5c ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-alanine--D-alanine_ligase D-alanine--D-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.4 6.3.2.4] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5c OCA], [http://pdbe.org/4c5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c5c RCSB], [http://www.ebi.ac.uk/pdbsum/4c5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c5c ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/C4ZRI7_ECOBW C4ZRI7_ECOBW]] Cell wall formation.[HAMAP-Rule:MF_00047][SAAS:SAAS00058712]
+[[https://www.uniprot.org/uniprot/DDLB_ECOLI DDLB_ECOLI]] Cell wall formation.
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, chemical and mechanistic studies here we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine proceeds via a distinct phosphorylated form of the drug. This mechanistic insight reveals a bimodal mechanism of action for a single antibiotic on different enzyme targets and has significance for the design of future inhibitor molecules based on this chemical structure.
-Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.,Batson S, de Chiara C, Majce V, Lloyd AJ, Gobec S, Rea D, Fulop V, Thoroughgood CW, Simmons KJ, Dowson CG, Fishwick CWG, de Carvalho LPS, Roper DI Nat Commun. 2017 Dec 5;8(1):1939. doi: 10.1038/s41467-017-02118-7. PMID:29208891<ref>PMID:29208891</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 4c5c" style="background-color:#fffaf0;"></div>
 ==See Also==
 *[[D-alanine-D-alanine ligase 3D structures|D-alanine-D-alanine ligase 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: D-alanine--D-alanine ligase]]
+[[Category: Escherichia coli K-12]]
-[[Category: Ecoli]]
 [[Category: Large Structures]]
-[[Category: Batson, S]]
+[[Category: Batson S]]
-[[Category: Fishwick, C W.G]]
+[[Category: Fishwick CWG]]
-[[Category: Fulop, V]]
+[[Category: Fulop V]]
-[[Category: Lloyd, A J]]
+[[Category: Lloyd AJ]]
-[[Category: Majce, V]]
+[[Category: Majce V]]
-[[Category: Rea, D]]
+[[Category: Rea D]]
-[[Category: Roper, D I]]
+[[Category: Roper DI]]
-[[Category: Simmons, K J]]
+[[Category: Simmons KJ]]
-[[Category: Ddlb]]
-[[Category: Ligase]]

4c5c

From Proteopedia

Revision as of 17:27, 7 September 2022

The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ADP and D-ala-D-ala

Structural highlights

Function

See Also

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox