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| | <StructureSection load='4d1g' size='340' side='right'caption='[[4d1g]], [[Resolution|resolution]] 1.90Å' scene=''> | | <StructureSection load='4d1g' size='340' side='right'caption='[[4d1g]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4d1g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ades1 Ades1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1G FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4d1g]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Snake_adenovirus_1 Snake adenovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D1G FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d0u|4d0u]], [[4d0v|4d0v]], [[4d1f|4d1f]], [[4d1h|4d1h]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1g OCA], [https://pdbe.org/4d1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d1g RCSB], [https://www.ebi.ac.uk/pdbsum/4d1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1g ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1g OCA], [http://pdbe.org/4d1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d1g RCSB], [http://www.ebi.ac.uk/pdbsum/4d1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1g ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [[https://www.uniprot.org/uniprot/SPIKE_ADES1 SPIKE_ADES1]] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Ades1]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Raaij, M J.van]] | + | [[Category: Snake adenovirus 1]] |
| - | [[Category: Singh, A K]] | + | [[Category: Singh AK]] |
| - | [[Category: Viral protein]] | + | [[Category: Van Raaij MJ]] |
| Structural highlights
Function
[SPIKE_ADES1]
Publication Abstract from PubMed
Adenoviruses are non-enveloped icosahedral viruses with trimeric fibre proteins protruding from their vertices. There are five known genera, from which only Mastadenoviruses have been widely studied. Apart from studying adenovirus as a biological model system and with a view to prevent or combat viral infection, there is a major interest in using adenovirus for vaccination, cancer therapy and gene therapy purposes. Adenoviruses from the Atadenovirus genus have been isolated from squamate reptile hosts, ruminants and birds and have a characteristic gene organization and capsid morphology. The carboxy-terminal virus-distal fibre head domains are likely responsible for primary receptor recognition. We determined the high-resolution crystal structure of the Snake Adenovirus 1 (SnAdV-1) fibre head using the multi-wavelength anomalous dispersion (MAD) method. Despite the absence of significant sequence homology, this Atadenovirus fibre head has the same beta-sandwich propeller topology as other adenovirus fibre heads. However, it is about half the size, mainly due to much shorter loops connecting the beta-strands. The detailed structure of the SnAdV-1 fibre head and other animal adenovirus fibre heads, together with the future identification of their natural receptors, may lead to the development of new strategies to target adenovirus vectors to cells of interest.
Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1.,Singh AK, Menendez-Conejero R, San Martin C, van Raaij MJ PLoS One. 2014 Dec 8;9(12):e114373. doi: 10.1371/journal.pone.0114373., eCollection 2014. PMID:25486282[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Singh AK, Menendez-Conejero R, San Martin C, van Raaij MJ. Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1. PLoS One. 2014 Dec 8;9(12):e114373. doi: 10.1371/journal.pone.0114373., eCollection 2014. PMID:25486282 doi:http://dx.doi.org/10.1371/journal.pone.0114373
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