6k5v
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CSY4 Apo-form== | |
| + | <StructureSection load='6k5v' size='340' side='right'caption='[[6k5v]], [[Resolution|resolution]] 2.69Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6k5v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K5V FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Citrate_synthase_(unknown_stereospecificity) Citrate synthase (unknown stereospecificity)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.16 2.3.3.16] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k5v OCA], [http://pdbe.org/6k5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k5v RCSB], [http://www.ebi.ac.uk/pdbsum/6k5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k5v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Citrate synthase (CS) catalyzes the conversion of oxaloacetate and acetyl coenzyme A into citrate and coenzyme A in the mitochondrial tricarboxylic acid (TCA) cycle. In plants, mitochondrial metabolism, including the TCA cycle, occurs in interaction with photosynthetic metabolism. The controlled regulation of several enzymes in the TCA cycle, such as CS, is important in plants. Here, the first crystal structure of a plant mitochondrial CS, CSY4 from Arabidopsis thaliana (AtCSY4), has been determined. Structural comparison of AtCSY4 with mitochondrial CSs revealed a high level of similarity. Inhibition analysis showed a similar manner of inhibition as in mitochondrial CSs. The effect of oxidation on one of a pair of cysteine residues in AtCSY4 was speculated upon based on the folded structure. | ||
| - | + | Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana.,Nishio K, Mizushima T Acta Crystallogr F Struct Biol Commun. 2020 Mar 1;76(Pt 3):109-115. doi:, 10.1107/S2053230X20001521. Epub 2020 Mar 1. PMID:32133996<ref>PMID:32133996</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6k5v" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mizushima, T]] | [[Category: Mizushima, T]] | ||
[[Category: Nishio, K]] | [[Category: Nishio, K]] | ||
| + | [[Category: Citrate synthase]] | ||
| + | [[Category: Csy4]] | ||
| + | [[Category: Mitochondrial]] | ||
| + | [[Category: Plant]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 09:39, 18 March 2020
Structure of CSY4 Apo-form
| |||||||||||
