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6qny
From Proteopedia
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| - | | + | #REDIRECT [[6qnx]] This PDB entry is obsolete and replaced by 6qnx |
| - | ==Structure of the SA2/SCC1/CTCF complex==
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| - | <StructureSection load='6qny' size='340' side='right'caption='[[6qny]], [[Resolution|resolution]] 2.40Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6qny]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QNY FirstGlance]. <br>
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| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qny OCA], [http://pdbe.org/6qny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qny RCSB], [http://www.ebi.ac.uk/pdbsum/6qny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qny ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/RAD21_HUMAN RAD21_HUMAN]] Cornelia de Lange syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22633399</ref>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/STAG2_HUMAN STAG2_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.<ref>PMID:12034751</ref> [[http://www.uniprot.org/uniprot/RAD21_HUMAN RAD21_HUMAN]] Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.<ref>PMID:12417729</ref> <ref>PMID:11875078</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Large Structures]]
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| - | [[Category: Li, Y]]
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| - | [[Category: Muir, K W]]
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| - | [[Category: Panne, D]]
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| - | [[Category: Chromatin folding]]
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| - | [[Category: Cohesin]]
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| - | [[Category: Ctcf]]
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| - | [[Category: Gene regulation]]
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| - | [[Category: Genome regulation]]
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| - | [[Category: Sa2]]
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| - | [[Category: Tad]]
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Current revision
- REDIRECT 6qnx This PDB entry is obsolete and replaced by 6qnx
