6ilu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:33, 27 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6ilu' size='340' side='right'caption='[[6ilu]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='6ilu' size='340' side='right'caption='[[6ilu]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6ilu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus_phage_pbc5 Bacillus cereus phage pbc5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ILU FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6ilu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PBC5 Bacillus phage PBC5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ILU FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.601&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PBC5_032 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1675030 Bacillus cereus phage PBC5])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ilu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilu OCA], [http://pdbe.org/6ilu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ilu RCSB], [http://www.ebi.ac.uk/pdbsum/6ilu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilu ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ilu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilu OCA], [https://pdbe.org/6ilu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ilu RCSB], [https://www.ebi.ac.uk/pdbsum/6ilu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilu ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/A0A218KCJ1_9CAUD A0A218KCJ1_9CAUD]
-
Phage endolysins are hydrolytic enzymes that cleave the bacterial cell wall during the lytic cycle. We isolated the bacteriophage PBC5 against Bacillus cereus, a major foodborne pathogen, and describe the molecular interaction between endolysin LysPBC5 and the host peptidoglycan structure. LysPBC5 has an N-terminal glycoside hydrolase 25 domain, and a C-terminal cell-wall binding domain (CBD) that is critical for specific cell-wall recognition and lysis. The crystal and solution structures of CBDs reveal tandem SH3b domains that are tightly engaged with each other. The CBD binds to the peptidoglycan in a bidentate manner via distal beta sheet motifs with pseudo 2-fold symmetry, which can explain its high affinity and host specificity. The CBD primarily interacts with the glycan strand of the peptidoglycan layer instead of the peptide crosslink, implicating the tertiary structure of peptidoglycan as the recognition motif of endolysins.
+
-
 
+
-
Structural Basis for Cell-Wall Recognition by Bacteriophage PBC5 Endolysin.,Lee KO, Kong M, Kim I, Bai J, Cha S, Kim B, Ryu KS, Ryu S, Suh JY Structure. 2019 Sep 3;27(9):1355-1365.e4. doi: 10.1016/j.str.2019.07.001. Epub, 2019 Jul 25. PMID:31353242<ref>PMID:31353242</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 6ilu" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
-
*[[Lysin|Lysin]]
+
*[[Lysin 3D structures|Lysin 3D structures]]
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus cereus phage pbc5]]
+
[[Category: Bacillus phage PBC5]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Bae, J W]]
+
[[Category: Bae JW]]
-
[[Category: Kim, I T]]
+
[[Category: Kim IT]]
-
[[Category: Kong, M S]]
+
[[Category: Kong MS]]
-
[[Category: Lee, K O]]
+
[[Category: Lee KO]]
-
[[Category: Ryu, K S]]
+
[[Category: Ryu KS]]
-
[[Category: Ryu, S]]
+
[[Category: Ryu S]]
-
[[Category: Suh, J Y]]
+
[[Category: Suh JY]]
-
[[Category: Cell-wall binding]]
+
-
[[Category: Endolysin]]
+
-
[[Category: Pbc5]]
+
-
[[Category: Sh3b]]
+
-
[[Category: Sugar binding protein]]
+

Current revision

Endolysin LysPBC5 CBD

PDB ID 6ilu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ilu"
Personal tools