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5qxr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with DF849== | |
| - | + | <StructureSection load='5qxr' size='340' side='right'caption='[[5qxr]], [[Resolution|resolution]] 1.66Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qxr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5QXR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RHY:1-[(4aS,7aS,9S)-3,4,7,7a,8,9-hexahydro-4a,9-epoxypyrrolo[3,4 4,5]cyclohepta[1,2-d]imidazol-6(5H)-yl]ethan-1-one'>RHY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5qxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxr OCA], [http://pdbe.org/5qxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qxr RCSB], [http://www.ebi.ac.uk/pdbsum/5qxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Adenosinetriphosphatase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Collins, P]] | ||
[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
| - | [[Category: | + | [[Category: Fowley, D]] |
| + | [[Category: Nelson, A]] | ||
[[Category: Snee, M]] | [[Category: Snee, M]] | ||
| - | [[Category: Bountra, C]] | ||
| - | [[Category: Arrowsmith, C.H]] | ||
| - | [[Category: Nelson, A]] | ||
| - | [[Category: Fowley, D]] | ||
[[Category: Talon, R]] | [[Category: Talon, R]] | ||
[[Category: Von-Delft, F]] | [[Category: Von-Delft, F]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Pandda]] | ||
| + | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
| + | [[Category: Xchemexplorer]] | ||
Revision as of 06:45, 8 April 2020
PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with DF849
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