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1aii

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[[Image:1aii.gif|left|200px]]
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{{STRUCTURE_1aii| PDB=1aii | SCENE= }}
{{STRUCTURE_1aii| PDB=1aii | SCENE= }}
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'''ANNEXIN III'''
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===ANNEXIN III===
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==Overview==
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Annexin III, a putative inositol (1,2)-phosphohydrolase, was co-crystallized with inositol 2-phosphate, the inhibitor of the reaction, and its structure was solved to 1.95 A resolution. No enzyme active site was observed in the structure. Assays for enzymatic activity were also negative. Search for annexin III-inositol phosphate interactions using the BIAcoreTM system revealed an affinity for inositol cyclic (1,2)-phosphate, suggesting annexin III may sequester the molecule in the cell. The BIAcoreTM system used with different phospholipids showed that annexin III displays specificity for phosphatidylethanolamine, but not for phosphatidylinositols. Interestingly, a molecule of ethanolamine was found bound to the protein in the crystal structure. Coupled with the fact that this is a particularly abundant phospholipid in granules specific to neutrophils, cells where annexin III is highly expressed, our finding could be pointing to a physiological role of annexin III.
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{{ABSTRACT_PUBMED_9111038}}
==About this Structure==
==About this Structure==
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[[Category: Calcium/phospholipid binding protein]]
[[Category: Calcium/phospholipid binding protein]]
[[Category: Phospholipase a2 inhibitor]]
[[Category: Phospholipase a2 inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:55:19 2008''

Revision as of 13:55, 30 June 2008

Image:1aii.png

Template:STRUCTURE 1aii

ANNEXIN III

Template:ABSTRACT PUBMED 9111038

About this Structure

1AII is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III?, Perron B, Lewit-Bentley A, Geny B, Russo-Marie F, J Biol Chem. 1997 Apr 25;272(17):11321-6. PMID:9111038

Page seeded by OCA on Mon Jun 30 16:55:19 2008

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