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4o9s

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Current revision (07:13, 25 January 2023) (edit) (undo)
 
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<StructureSection load='4o9s' size='340' side='right'caption='[[4o9s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4o9s' size='340' side='right'caption='[[4o9s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2RY:1-[4-(8LAMBDA~4~-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDIN-4-YL)PIPERAZIN-1-YL]-2-[2-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>2RY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2RY:1-[4-(8LAMBDA~4~-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDIN-4-YL)PIPERAZIN-1-YL]-2-[2-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>2RY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fmz|3fmz]], [[4psq|4psq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9s OCA], [https://pdbe.org/4o9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9s RCSB], [https://www.ebi.ac.uk/pdbsum/4o9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9s ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBP4, PRO2222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9s OCA], [http://pdbe.org/4o9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o9s RCSB], [http://www.ebi.ac.uk/pdbsum/4o9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9s ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Johnstone, S]]
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[[Category: Johnstone S]]
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[[Category: Walker, N P]]
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[[Category: Walker NP]]
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[[Category: Wang, Z]]
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[[Category: Wang Z]]
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[[Category: Disease mutation]]
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[[Category: Protein binding]]
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[[Category: Retinol binding]]
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[[Category: Retinol-binding]]
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[[Category: Secreted]]
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[[Category: Sensory transduction]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Vision]]
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[[Category: Vitamin some]]
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Current revision

Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand

PDB ID 4o9s

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