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2b4n

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Revision as of 13:05, 24 November 2021

Solution Structure of Glucose-Dependent Insulinotropic Polypeptide

Structural highlights

2b4n is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GIP_HUMAN] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

Publication Abstract from PubMed

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates the secretion of insulin after ingestion of food. GIP also promotes the synthesis of fatty acids in adipose tissue. Therefore, it is not surprising that numerous literature reports have shown that GIP is linked to diabetes and obesity-related diseases. In this study, we present the solution structure of GIP in water determined by NMR spectroscopy. The calculated structure is characterized by the presence of an alpha-helical motif between residues Ser(11) and Gln(29). The helical conformation of GIP is further supported by CD spectroscopic studies. Six GIP-(1-42)Ala(1-7) analogues were synthesized by replacing individual N-terminal residues with alanine. Alanine scan studies of these N-terminal residues showed that the GIP-(1-42)Ala(6) was the only analogue to show insulin-secreting activity similar to that of the native GIP. However, when compared with glucose, its insulinotropic ability was reduced. For the first time, these NMR and modeling results contribute to the understanding of the structural requirements for the biological activity of GIP.

NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water.,Alana I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM J Biol Chem. 2006 Jun 16;281(24):16370-6. Epub 2006 Apr 18. PMID:16621806^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Alana I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM. NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water. J Biol Chem. 2006 Jun 16;281(24):16370-6. Epub 2006 Apr 18. PMID:16621806 doi:M510414200

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b4n"

@@ Line 3: / Line 3: @@
 <StructureSection load='2b4n' size='340' side='right'caption='[[2b4n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2b4n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B4N FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2b4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B4N FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4n OCA], [http://pdbe.org/2b4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b4n RCSB], [http://www.ebi.ac.uk/pdbsum/2b4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b4n ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4n OCA], [https://pdbe.org/2b4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b4n RCSB], [https://www.ebi.ac.uk/pdbsum/2b4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b4n ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN]] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
+[[https://www.uniprot.org/uniprot/GIP_HUMAN GIP_HUMAN]] Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

2b4n

From Proteopedia

Revision as of 13:05, 24 November 2021

Solution Structure of Glucose-Dependent Insulinotropic Polypeptide

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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