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6lpb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein== | |
| - | + | <StructureSection load='6lpb' size='340' side='right'caption='[[6lpb]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6lpb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LPB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lpb OCA], [http://pdbe.org/6lpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lpb RCSB], [http://www.ebi.ac.uk/pdbsum/6lpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lpb ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/PACA_HUMAN PACA_HUMAN]] Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.<ref>PMID:11175907</ref> [[http://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/PACR_HUMAN PACR_HUMAN]] This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kobayashi, K]] | ||
| + | [[Category: Nishizawa, T]] | ||
[[Category: Nureki, O]] | [[Category: Nureki, O]] | ||
| - | [[Category: Nishizawa, T]] | ||
| - | [[Category: Kobayashi, K]] | ||
[[Category: Shihoya, W]] | [[Category: Shihoya, W]] | ||
| + | [[Category: Class b gpcr]] | ||
| + | [[Category: Pac1r]] | ||
| + | [[Category: Pacap]] | ||
| + | [[Category: Signaling protein-hormone complex]] | ||
Revision as of 07:20, 11 March 2020
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein
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