1q2w

<StructureSection load='1q2w' size='340' side='right'caption='[[1q2w]], [[Resolution|resolution]] 1.86&Aring;' scene=''>

<table><tr><td colspan='2'>[[1q2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q2W FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q2w OCA], [http://pdbe.org/1q2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q2w RCSB], [http://www.ebi.ac.uk/pdbsum/1q2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q2w ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>

*[[SARS Coronavirus Main Proteinase|SARS Coronavirus Main Proteinase]]

[[Category: Cvhsa]]

[[Category: Bonanno, J B]]

[[Category: Burley, S K]]

[[Category: Fowler, R]]

[[Category: Gupta, S]]

[[Category: Harris, T]]

[[Category: Hendle, J]]

[[Category: Liu, E T]]

[[Category: Lorimer, D]]

[[Category: Romero, R]]

[[Category: Sauder, J M]]

[[Category: Wei, C L]]

[[Category: Sars-cov main protease]]