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1al4

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{{STRUCTURE_1al4| PDB=1al4 | SCENE= }}
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'''GRAMICIDIN D FROM BACILLUS BREVIS (N-PROPANOL SOLVATE)'''
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===GRAMICIDIN D FROM BACILLUS BREVIS (N-PROPANOL SOLVATE)===
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==Overview==
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The linear pentadecapeptide antibiotic gramicidin D is a heterogeneous mixture of six components. Precise refinements of three-dimensional structures of naturally occurring gramicidin D in crystals obtained from methanol, ethanol, and n-propanol demonstrate the unexpected presence of stable left-handed antiparallel double-helical heterodimers that vary with the crystallization solvent. The side chains of Trp residues in the three structures exhibit sequence-specific patterns of conformational preference. Tyr substitution for Trp at position 11 appears to favor beta ribbon formation and stabilization of the antiparallel double helix that acts as a template for gramicidin folding and nucleation of different crystal forms. The fact that a minor component in a heterogeneous mixture influences aggregation and crystal nucleation has potential applications to other systems in which anomalous behavior is exhibited by aggregation of apparently homogeneous materials, such as the enigmatic behavior of prion proteins.
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==About this Structure==
==About this Structure==
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[[Category: Pangborn, W A.]]
[[Category: Pangborn, W A.]]
[[Category: Peptide antibiotic]]
[[Category: Peptide antibiotic]]
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Revision as of 14:04, 30 June 2008

Image:1al4.png

Template:STRUCTURE 1al4

GRAMICIDIN D FROM BACILLUS BREVIS (N-PROPANOL SOLVATE)

Template:ABSTRACT PUBMED 9788907

About this Structure

Full crystallographic information is available from OCA.

Reference

Heterodimer formation and crystal nucleation of gramicidin D., Burkhart BM, Gassman RM, Langs DA, Pangborn WA, Duax WL, Biophys J. 1998 Nov;75(5):2135-46. PMID:9788907

Page seeded by OCA on Mon Jun 30 17:04:42 2008

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