6rkb

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Current revision (12:22, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6rkb' size='340' side='right'caption='[[6rkb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6rkb' size='340' side='right'caption='[[6rkb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rkb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RKB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rkb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RKB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=K6Q:4-[(~{E})-2-(4-fluorophenyl)ethenyl]-1-[(~{E})-prop-1-enyl]piperidine'>K6Q</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAOB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=K6Q:4-[(~{E})-2-(4-fluorophenyl)ethenyl]-1-[(~{E})-prop-1-enyl]piperidine'>K6Q</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rkb OCA], [https://pdbe.org/6rkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rkb RCSB], [https://www.ebi.ac.uk/pdbsum/6rkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rkb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rkb OCA], [http://pdbe.org/6rkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rkb RCSB], [http://www.ebi.ac.uk/pdbsum/6rkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rkb ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6rkb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6rkb" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoamine oxidase|Monoamine oxidase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Monoamine oxidase]]
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[[Category: Binda C]]
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[[Category: Binda, C]]
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[[Category: Colettis N]]
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[[Category: Colettis, N]]
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[[Category: Dolsak A]]
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[[Category: Dolsak, A]]
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[[Category: Gobec S]]
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[[Category: Gobec, S]]
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[[Category: Higgs J]]
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[[Category: Higgs, J]]
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[[Category: Iacovino LG]]
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[[Category: Iacovino, L G]]
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[[Category: Kamecki F]]
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[[Category: Kamecki, F]]
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[[Category: Knez D]]
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[[Category: Knez, D]]
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[[Category: Kos J]]
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[[Category: Kos, J]]
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[[Category: Mangialavori I]]
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[[Category: Mangialavori, I]]
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[[Category: Marder NM]]
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[[Category: Marder, N M]]
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[[Category: Pislar A]]
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[[Category: Pislar, A]]
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[[Category: Sova M]]
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[[Category: Sova, M]]
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[[Category: Trontelj J]]
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[[Category: Trontelj, J]]
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[[Category: Zakelj S]]
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[[Category: Zakelj, S]]
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[[Category: Drug target]]
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[[Category: Flavin]]
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[[Category: Flavoprotein]]
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[[Category: Isomer]]
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[[Category: Mitochondrial membrane]]
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[[Category: Neurodegeneration]]
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Current revision

Crystal structure of human monoamine oxidase B in complex with styrylpiperidine analogue 1

PDB ID 6rkb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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