6tmf

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==Structure of an archaeal ABCE1-bound ribosomal post-splitting complex==
==Structure of an archaeal ABCE1-bound ribosomal post-splitting complex==
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<StructureSection load='6tmf' size='340' side='right'caption='[[6tmf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<SX load='6tmf' size='340' side='right' viewer='molstar' caption='[[6tmf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6tmf]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer_dsm_2476 Thermococcus celer dsm 2476] and [http://en.wikipedia.org/wiki/Thermococcus_celer_vu_13_=_jcm_8558 Thermococcus celer vu 13 = jcm 8558]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TMF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6tmf]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer_dsm_2476 Thermococcus celer dsm 2476] and [http://en.wikipedia.org/wiki/Thermococcus_celer_vu_13_=_jcm_8558 Thermococcus celer vu 13 = jcm 8558]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TMF FirstGlance]. <br>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A218P4M9_THECE A0A218P4M9_THECE]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/A0A218P4N5_THECE A0A218P4N5_THECE]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/A0A218NZW1_THECE A0A218NZW1_THECE]] Binds 16S rRNA, required for the assembly of 30S particles.[HAMAP-Rule:MF_01364] [[http://www.uniprot.org/uniprot/A0A218P4W7_THECE A0A218P4W7_THECE]] May be involved in maturation of the 30S ribosomal subunit.[HAMAP-Rule:MF_01474] [[http://www.uniprot.org/uniprot/A0A218NZT2_THECE A0A218NZT2_THECE]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.[HAMAP-Rule:MF_01315] [[http://www.uniprot.org/uniprot/A0A218P3Q8_THECE A0A218P3Q8_THECE]] Involved in the binding of tRNA to the ribosomes.[HAMAP-Rule:MF_00508][SAAS:SAAS00243318] [[http://www.uniprot.org/uniprot/A0A218P167_THECE A0A218P167_THECE]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.[HAMAP-Rule:MF_00326] [[http://www.uniprot.org/uniprot/A0A218NZU7_THECE A0A218NZU7_THECE]] Binds the lower part of the 30S subunit head.[HAMAP-Rule:MF_01309] [[http://www.uniprot.org/uniprot/A0A218P4K4_THECE A0A218P4K4_THECE]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.[HAMAP-Rule:MF_00480] [[http://www.uniprot.org/uniprot/A0A218NZU0_THECE A0A218NZU0_THECE]] Located on the platform of the 30S subunit.[HAMAP-Rule:MF_01310] [[http://www.uniprot.org/uniprot/A0A218P4I2_THECE A0A218P4I2_THECE]] With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.[HAMAP-Rule:MF_00403][RuleBase:RU004490] [[http://www.uniprot.org/uniprot/A0A218NZX3_THECE A0A218NZX3_THECE]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.[HAMAP-Rule:MF_01345] [[http://www.uniprot.org/uniprot/A0A218NZT7_THECE A0A218NZT7_THECE]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/A0A218NZV3_THECE A0A218NZV3_THECE]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.[HAMAP-Rule:MF_01306][SAAS:SAAS00896430] With S5 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01306][SAAS:SAAS00896433]
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[[http://www.uniprot.org/uniprot/A0A218P4M9_THECE A0A218P4M9_THECE]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/A0A218P4N5_THECE A0A218P4N5_THECE]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/A0A218NZW1_THECE A0A218NZW1_THECE]] Binds 16S rRNA, required for the assembly of 30S particles.[HAMAP-Rule:MF_01364] [[http://www.uniprot.org/uniprot/A0A218P4W7_THECE A0A218P4W7_THECE]] May be involved in maturation of the 30S ribosomal subunit.[HAMAP-Rule:MF_01474] [[http://www.uniprot.org/uniprot/A0A218P3Q8_THECE A0A218P3Q8_THECE]] Involved in the binding of tRNA to the ribosomes.[HAMAP-Rule:MF_00508][SAAS:SAAS00243318] [[http://www.uniprot.org/uniprot/A0A218NZT2_THECE A0A218NZT2_THECE]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.[HAMAP-Rule:MF_01315] [[http://www.uniprot.org/uniprot/A0A218P167_THECE A0A218P167_THECE]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.[HAMAP-Rule:MF_00326] [[http://www.uniprot.org/uniprot/A0A218NZU7_THECE A0A218NZU7_THECE]] Binds the lower part of the 30S subunit head.[HAMAP-Rule:MF_01309] [[http://www.uniprot.org/uniprot/A0A218P4K4_THECE A0A218P4K4_THECE]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.[HAMAP-Rule:MF_00480] [[http://www.uniprot.org/uniprot/A0A218NZU0_THECE A0A218NZU0_THECE]] Located on the platform of the 30S subunit.[HAMAP-Rule:MF_01310] [[http://www.uniprot.org/uniprot/A0A218P4I2_THECE A0A218P4I2_THECE]] With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.[HAMAP-Rule:MF_00403][RuleBase:RU004490] [[http://www.uniprot.org/uniprot/A0A218NZT7_THECE A0A218NZT7_THECE]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/A0A218NZX3_THECE A0A218NZX3_THECE]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.[HAMAP-Rule:MF_01345] [[http://www.uniprot.org/uniprot/A0A218NZV3_THECE A0A218NZV3_THECE]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.[HAMAP-Rule:MF_01306][SAAS:SAAS00896430] With S5 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01306][SAAS:SAAS00896433]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thermococcus celer dsm 2476]]
[[Category: Thermococcus celer dsm 2476]]

Revision as of 01:01, 7 March 2020

Structure of an archaeal ABCE1-bound ribosomal post-splitting complex

6tmf, resolution 2.80Å

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