4ux6

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<StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [https://pdbe.org/4ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [http://pdbe.org/4ux6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Andrews, G]]
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[[Category: Andrews G]]
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[[Category: Beaton, H G]]
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[[Category: Beaton HG]]
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[[Category: Birkinshaw, T]]
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[[Category: Birkinshaw T]]
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[[Category: Boughton-Smith, N]]
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[[Category: Boughton-Smith N]]
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[[Category: Cheshire, D R]]
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[[Category: Cheshire DR]]
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[[Category: Connolly, S]]
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[[Category: Connolly S]]
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[[Category: Cook, T R]]
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[[Category: Cook TR]]
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[[Category: Cooper, A]]
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[[Category: Cooper A]]
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[[Category: Cooper, S L]]
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[[Category: Cooper SL]]
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[[Category: Cox, D]]
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[[Category: Cox D]]
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[[Category: Dixon, J]]
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[[Category: Dixon J]]
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[[Category: Gensmantel, N]]
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[[Category: Gensmantel N]]
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[[Category: Hamley, P J]]
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[[Category: Hamley PJ]]
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[[Category: Harrison, R]]
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[[Category: Harrison R]]
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[[Category: Hartopp, P]]
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[[Category: Hartopp P]]
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[[Category: Kack, H]]
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[[Category: Kack H]]
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[[Category: Luker, T]]
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[[Category: Luker T]]
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[[Category: Mete, A]]
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[[Category: Mete A]]
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[[Category: Millichip, I]]
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[[Category: Millichip I]]
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[[Category: Nicholls, D J]]
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[[Category: Nicholls DJ]]
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[[Category: Pimm, A D]]
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[[Category: Pimm AD]]
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[[Category: St-Gallay, S A]]
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[[Category: St-Gallay SA]]
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[[Category: Wallace, A V]]
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[[Category: Wallace AV]]
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[[Category: Drug design]]
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[[Category: Oxidoreductase]]
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Revision as of 07:48, 29 March 2023

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

PDB ID 4ux6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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