CTLA-4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
CTLA4/152 Cytotoxic T-Lymphocyte Associated Protein
+
 
<StructureSection load='1stp' size='340' side='right' caption='CTLA4 Caption for this structure' scene=''>
<StructureSection load='1stp' size='340' side='right' caption='CTLA4 Caption for this structure' scene=''>
Line 5: Line 5:
-
Function: CTLA4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA4 transmits an inhibitory signal to T cells,[10][11][12][7] whereas CD28 transmits a stimulatory signal.[13][14] CTLA4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4.
+
== Function ==
 +
 +
'''CTLA4''' or '''Cytotoxic T-Lymphocyte Associated protein 4''' is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA4 transmits an inhibitory signal to T cells,[10][11][12][7] whereas CD28 transmits a stimulatory signal.[13][14] CTLA4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4<ref>PMID:7939684</ref>.
 +
 
 +
== Disease ==
 +
 
 +
Variants in this gene have been associated with Type 1 diabetes, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases.
 +
 
 +
== Structural highlights ==
 +
 
 +
The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28,
 +
 
 +
</StructureSection
 +
 
 +
==3D structures of CTLA-4==
-
Disease: Variants in this gene have been associated with Type 1 diabetes, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases.
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-
Structural highlights: The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28,
+
[[2x44]], [[3osk]] - hCTLA-4 - human <br />
 +
[[1ah1]] - hCTLA-4 - NMR<br />
 +
[[5ggv]], [[5tru]], [[5xj3]], [[6rp8]], [[6xy2]] - hCTLA-4 + antibody <br />
 +
[[6rpj]], [[6rqm]] - hCTLA-4 + nanobody <br />
 +
[[1i8l]] - hCTLA-4 + CD80<br />
 +
[[1i85]] - hCTLA-4 + CD86<br />
 +
[[3bx7]] - hCTLA-4 + LCN2<br />
 +
[[7cio]] - hCTLA-4 + PI3K<br />
 +
[[4kkn]] - CTLA-4 - bovine<br />
 +
[[1dqt]], [[5e56]] - mCTLA-4 - mouse<br />
 +
[[5e5m]] - mCTLA-4 + nanobody <br />
 +
== References ==
 +
<references/>
 +
[[Category:Topic Page]]
References https://www.wikiwand.com/en/CTLA-4
References https://www.wikiwand.com/en/CTLA-4

Revision as of 08:00, 8 February 2021


CTLA4 Caption for this structure

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Supriya Pal Sharma, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/CTLA-4"
Personal tools