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6lvs

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'''Unreleased structure'''
 
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The entry 6lvs is ON HOLD until Mar 03 2021
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==USP14 catalytic domain mutant C114S==
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<StructureSection load='6lvs' size='340' side='right'caption='[[6lvs]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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Authors: Lin, H.C., Lin, T.H., Chou, C.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6lvs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LVS FirstGlance]. <br>
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Description: USP14 catalytic domain mutant C114S
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
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[[Category: Chou, C.Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvs OCA], [http://pdbe.org/6lvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lvs RCSB], [http://www.ebi.ac.uk/pdbsum/6lvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvs ProSAT]</span></td></tr>
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[[Category: Lin, H.C]]
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</table>
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[[Category: Lin, T.H]]
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== Function ==
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[[http://www.uniprot.org/uniprot/UBP14_HUMAN UBP14_HUMAN]] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).<ref>PMID:18162577</ref> <ref>PMID:19135427</ref> <ref>PMID:19106094</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Chou, C Y]]
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[[Category: Lin, H C]]
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[[Category: Lin, T H]]
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[[Category: Hydrolase]]
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[[Category: Protein deubiquitination]]
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[[Category: Ubiquitin dependent protein catabolic process]]

Revision as of 09:41, 18 March 2020

USP14 catalytic domain mutant C114S

PDB ID 6lvs

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