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6ici

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Current revision (09:37, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6ici' size='340' side='right'caption='[[6ici]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6ici' size='340' side='right'caption='[[6ici]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ici]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ICI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ICI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ici]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ICI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ICI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/F-actin_monooxygenase F-actin monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.225 1.14.13.225] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ici FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ici OCA], [http://pdbe.org/6ici PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ici RCSB], [http://www.ebi.ac.uk/pdbsum/6ici PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ici ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ici FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ici OCA], [https://pdbe.org/6ici PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ici RCSB], [https://www.ebi.ac.uk/pdbsum/6ici PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ici ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MICA3_HUMAN MICA3_HUMAN]] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.<ref>PMID:21596566</ref>
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[https://www.uniprot.org/uniprot/MICA3_HUMAN MICA3_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.<ref>PMID:21596566</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: F-actin monooxygenase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hwang, K Y]]
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[[Category: Hwang KY]]
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[[Category: Kim, J S]]
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[[Category: Kim JS]]
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[[Category: Flavoprotein]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human MICAL3

PDB ID 6ici

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