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1amt

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{{STRUCTURE_1amt| PDB=1amt | SCENE= }}
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'''A VOLTAGE-GATED ION CHANNEL MODEL INFERRED FROM THE CRYSTAL STRUCTURE OF ALAMETHICIN AT 1.5-ANGSTROMS RESOLUTION'''
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===A VOLTAGE-GATED ION CHANNEL MODEL INFERRED FROM THE CRYSTAL STRUCTURE OF ALAMETHICIN AT 1.5-ANGSTROMS RESOLUTION===
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==Overview==
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The crystal structure of alamethicin in nonaqueous solvent has been determined, and refined at 1.5-A resolution. The molecular conformation of the three crystallographically independent molecules is largely alpha-helical with a bend in the helix axis at an internal proline residue. The helix structure is highly amphipathic as most of the solvent-accessible polar atoms lie on a narrow strip of surface parallel to the helix axis. Molecular models for the voltage-gated ion channel, with n-fold symmetry and based on the molecular conformations observed in the crystal, are characterized by strong surface complementarity, a hydrophilic interior and a hydrophobic exterior. The channel structures are stabilized by a hydrated annulus of hydrogen-bonded glutamine residues which produce the greatest restriction in the channel diameter.
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The line below this paragraph, {{ABSTRACT_PUBMED_6292726}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 6292726 is the PubMed ID number.
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{{ABSTRACT_PUBMED_6292726}}
==About this Structure==
==About this Structure==
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[[Category: Richards, F M.]]
[[Category: Richards, F M.]]
[[Category: Peptide antibiotic]]
[[Category: Peptide antibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:27:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:11:14 2008''

Revision as of 14:11, 30 June 2008

Image:1amt.png

Template:STRUCTURE 1amt

A VOLTAGE-GATED ION CHANNEL MODEL INFERRED FROM THE CRYSTAL STRUCTURE OF ALAMETHICIN AT 1.5-ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 6292726

About this Structure

Full crystallographic information is available from OCA.

Reference

A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution., Fox RO Jr, Richards FM, Nature. 1982 Nov 25;300(5890):325-30. PMID:6292726

Page seeded by OCA on Mon Jun 30 17:11:14 2008

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